Blake Marggraff
Chief Experience Officer, TCARE
Blake founded and grew CareSignal, developing evidence-based healthcare technology to deliver clinical and financial returns for patients and healthcare organizations who have the most to gain. CareSignal started in 2015, born out of clinical research covering thousands of patients, and subsequently scaling its Deviceless Remote Patient Monitoring solution to millions of underserved or high-risk patients across the United States. CareSignal was acquired by the leading population health company, Lightbeam Health Solutions, in November 2021. The company’s technology has been recognized by the 2018 Forbes Impact Summit and KLAS as "Best in KLAS for RPM," and its clinical impact is evidenced by 10+ positive-outcome peer reviewed journal publications and myriad propensity-matched claims analysis-based case studies. Blake has experience as in hard sciences research, and previously co-founded and grew the education technology startup BetaBox Labs to cashflow positive. Blake is deeply mission-driven, having founded CareSignal with the intent to make it new standard of care for United States patients across the most prevalent chronic and behavioral health conditions, aligned with his long-term personal vision of adding one billion QALYs (quality-adjusted life years) to humankind.
Blake grew up in the Bay Area of California and now resides in Dallas, TX. An Eagle Scout, his favorite merit badges were nuclear science and entrepreneurship. What began as a home-brew x-ray machine in the back of a public high school classroom led Blake to win the Intel Science and Engineering Fair in 2011 by using tin microparticles to improve cancer treatment, for which he was named top Teenage Inventor by Popular Science. Blake attended Washington University’s undergraduate Biology program, graduating in 2015. Blake has served on the board of the healthcare access nonprofit IFM Family Medicine among others, mentors health tech entrepreneurs from the University of Missouri St. Louis (UMSL) and WUSTL, and enjoys backpacking and advising digital healthcare startups.
All Sessions by Blake Marggraff
Track A - Scaling Science: The Next Stage for St. Louis' HealthTech & Biotech Innovators
Enterprise RoomAs St. Louis continues to emerge as a national leader in HealthTech and Biotech innovation, a new wave of startups is moving beyond early-stage success and into high-growth expansion. This panel will feature founders and executives from the region’s fastest-growing health and life sciences companies who have recently secured growth capital investment (some Series B & C), positioning them for rapid scaling, commercialization, and broader market impact. Panelists will discuss the evolving investment landscape, the strategic milestones that attract later-stage capital, and how they are leveraging funding to expand operations, accelerate clinical development, navigate regulatory pathways, and enter new markets. With growing support from venture capital, corporate partnerships, and a maturing ecosystem, St. Louis’ HealthTech and Biotech scaleups are proving that breakthrough science can translate into high-growth businesses that drive economic and healthcare transformation.